Surviving the World stretches the definition of a webcomic, in that the only real "character" is Dante Shepherd, the creator. Each day, he posts a lesson on a blackboard (well, it's really green, but it appears to be in a real classroom), and takes a picture with himself in-frame. On Fridays, he entertains questions from the "class" of his readers.
His white labcoat is set off by a Red Sox cap (my college career was not such that I can tell if this is unusual, but it's a great look nonetheless), and he seems to make a point of trying to act out his response to the lesson.
He just hit 1000 comics. Check it out.